Comparative Study on the Effect of Intraperitoneal Hyperthermia Chemotherapy on Cancerous Ascites of Different Temperatures

Authors

  • Zongzhi Liang Henan Provincial Hospital
  • Yapeng Huang
  • Junfang Pang
  • Bin Li
  • Jingna Wang
  • Shengnan Hu
  • Huizhen Zhang

Keywords:

intraperitoneal hyperthermia chemotherapy, cancerous ascites, hyperthermia temperature

Abstract

Objective: The difference of curative effects of intraperitoneal hyperthermia chemotherapy in the treatment of cancerous ascites with different action temperatures was studied. 

Methods: 200 cases of patients with malignant ascites from our hospital that treated with the intraperitoneal hyperthermia chemotherapy during 2004 to 2020 were selected, among which 100 cases in observation group had hyperthermia temperature of 43℃ and 100 cases in control group had hyperthermia temperature of 42℃. The short/long-term curative effects, half-year and one-year survival period, and post-treatment complications of the two groups of patients were compared and analyzed. 

Results: The total efficacy of 43℃ intraperitoneal hyperthermia chemotherapy group of patients was 91%, and the total efficacy of control group 42℃ was 62%. The half-year survival of 43℃ observation group was 96%, and one-year survival was 87%; while the half-year survival of control group was 66%, and one-year survival was 51%. Conclusion: the clinical treatment efficacy of patients treated with 43℃ intraperitoneal hyperthermia chemotherapy was notably better than the patients treated with 42℃ intraperitoneal hyperthermia chemotherapy.  There was statistical difference in the adverse reactions between the two groups of patients after treatment.

References

Zhang Feifei , Kim Sai-chu , Liu handsome self . Malignant ascites New Treatment [J]. Journal of Gastroenterology and Hepatology , 2017,26 (04): 476-478.

Xiao Shaowen , Wu Zhibing , Zhang Ke . Chinese expert consensus on tumor hyperthermia [J]. Journal of Practical Oncology , 2020,35(01):1-10.

Wu Shizhen . Observation of the clinical effect of apatinib in the treatment of advanced gastric cancer with refractory cancerous ascites [J]. Journal of Clinical Rational Use , 2018,11(20):53-54.

Chen Yi , Zhu Peng , Zhang Jianbo . Research progress of intraperitoneal hyperthermic perfusion chemotherapy in the treatment of advanced gastric cancer with malignant ascites [J]. Modern Medicine and Health , 2018,34(21):3339-3341+3416.

Zhang Zetian, Xu Guangwei . Oncology [M]. Tianjin Science and Technology Press, 1999:842-850.

Weiming Qin , Xu XiMing . Hyperthermia, sorafenib joint involvement of primary liver cancer . [J] Modern Medicine , 2014,23 (36): 4006-4009.

Fan Yufei , Qin Yuan , Li Dinggang . The effect of recombinant human P53 adenovirus injection combined with local hyperthermia and chemotherapy in the treatment of advanced pancreatic cancer [J] .China Contemporary Medicine ,2017,24(13):85.

Yang Jian , Guo Xinhong , Lu Wei et al . Evaluation and analysis of clinical efficacy of interventional chemoembolization combined with extracorporeal hyperthermia for advanced liver cancer [J]. Chinese Journal of Modern Surgery , 2015,19(03):186.

Liu Yangfan, Wan Lixin, Gao Jianbu, Qu Zhongyu, Sun Xing, Zhao Debao, Wang Wenlian, Song Fei.Effects of continuous hyperthermic perfusion chemotherapy on tumor markers in elderly patients with malignant pleural effusion[J].Chinese Journal of Gerontology, 2020,40(02):304-307.

Liang Anlin , Li Zhuori , Zhou Kailun , Zheng Jinfang , Sun Qigang , Wu Jincai . Hyperthermia methods and new developments in liver cancer [J]. Hainan Medicine , 2013,24(12):1789-1792.

Li Yazhe , Zhang Yang , Sun Jinghua . Research progress on the effects of deep hyperthermia on the immune function of pancreatic cancer [J] .Journal of Dalian Medical University ,2019,41(02):175.

Shen Wenming . In vitro experimental study on heating-induced apoptosis of gastric cancer cells [J]. Modern Medicine and Health ,2011,27(19):2898-2900 .

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Published

2021-09-22 — Updated on 2021-09-23

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